Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC 5-Propargyltryptamide formic | 2906227-87-8 | 99.9% | 260.29 g/mol | C14H16N2O3 | 10 MG
5-PT formic (5-Propargyltryptamide formic) is a serotonin-derived chemical probe containing a propargyl (alkyne) moiety for copper-catalyzed azide-alkyne cycloaddition (click chemistry). It is used to label and study protein serotonylation in biochemical and cell-based assays.
- Enables copper-catalyzed click chemistry labeling of serotonylated proteins.
- High chemical purity (99.91%).
- Solid, white to off-white physical form for easy handling and storage.
- Suitable for biochemical and cell-based assay applications.
- Available in small-scale quantities (for example, 10 mg) for exploratory studies.
Medchemexpress LLC PKCiota-IN-2 formic | 99.0% | 402.36 | 100 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι) with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε.
- Potent PKCiota (PKC-ι) inhibitor.
- Inhibits PKC-α and PKC-ε.
- Available in solid and solution forms.
- Purity: 99.04%.
- For research use only.
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 100g
Formic acid ammonium salt is an endogenous metabolite
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 2.5kg | 480143864
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 2.5kg | 480143864
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 100 MG
CCT367766 formic is a potent, third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC). It depletes pirin protein expression at low concentrations. CCT367766 formic shows a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. It also reveals a good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. This compound provides a potential chemical tool to study a largely unexplored protein.
- Depletes pirin protein expression at low concentrations.
- Moderate affinity for CRBN-DDB1 complex with an IC50 value of 490 nM.
- Good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM.
- Potential chemical tool for studying largely unexplored proteins.
Sigma Aldrich Fine Chemicals Biosciences FORMIC ACID, PURISS. P.A.,2.5L
Formic Acid, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98% 2.5L
U.S. Pharmacopeia Formic Acid (1.2 mL/ampule; 3 ampules) | 64-18-6 | MFCD00003297
Formic Acid (1.2 mL/ampule; 3 ampules) | Mol Wt: 46.025 | 64-18-6 | MFCD00003297 |
eMolecules Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
Ambeed / Ammonium formate / 25g / 506390793 / A414767 / / 540-69-2 / MFCD00013103 / 63.056 / CH5NO2
Medchemexpress LLC Slb1122168 formic | 2999629-17-1 | 99.9% | 403.56 | C23H37N3O3 | 10 MG
SLB1122168 formic is a research-stage small molecule that inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release. It has reported in vitro potency and is supplied for laboratory research with recommended storage and handling per the Safety Data Sheet.
Medchemexpress LLC PKCiota-IN-2 formic | 99.0% | 402.36 | 1 ML
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. It also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively.
- Potent PKCiota inhibitor with an IC50 of 2.8 nM.
- Also inhibits PKC-α with an IC50 of 71 nM.
- Inhibits PKC-ε with an IC50 of 350 nM.