Formic Acid
Medchemexpress LLC PKCiota-IN-2 formic | 99.04% | 402.36 | 50 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι), with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε, exhibiting IC50s of 71 nM and 350 nM, respectively. This product is intended for research use only and is not for sale to patients.
- Potent inhibition of PKCiota.
- Exhibits inhibitory effects on PKC-alpha and PKC-epsilon.
- Available in various quantities, including solid and solution forms.
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 | 10 MG
CCT367766 formic is a potent, third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. It effectively depletes pirin protein expression at low concentrations and provides a potential chemical tool for studying this largely unexplored protein.
- Exhibits moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM.
- Demonstrates good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively.
- Depletes pirin protein in SK-OV-3 human ovarian cancer cells in a time-dependent manner.
- Rescues pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 50 MG
CCT367766 formic is a potent third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. This PROTAC effectively depletes pirin protein expression at low concentrations. It demonstrates a moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM. Furthermore, it shows good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. This product serves as a valuable chemical tool for researching a protein that is currently not well understood.
- Potent third-generation PROTAC.
- Targets pirin protein degradation.
- Moderate affinity for the CRBN-DDB1 complex (IC50 = 490 nM).
- Good affinity for recombinant pirin (Kd = 55 nM) and CRBN (Kd = 120 nM).
- Useful chemical tool for pirin protein studies.
Sigma Aldrich Fine Chemicals Biosciences Formic acid | 64-18-6 | MFCD00003297 | 1 L
Formic acid | Purity: 98% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 1 L
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 4X100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 4X100ML
Medchemexpress LLC Bisindolylmaleimide IX formic | 00-00-0 | 96.0% | C26H25N5O4S | 10MG
Ro 31-8220 formic is a small-molecule research reagent that acts as a potent, cell-permeable inhibitor of protein kinase C (PKC) and several other kinases. It is used in biochemical and cellular studies to probe PKC-dependent signaling, kinase selectivity, and downstream pathway effects such as JNK activation and c-Jun induction.
- Potent PKC inhibition with low-nanomolar IC50s.
- Inhibits multiple kinases for broad pathway interrogation.
- Cell-permeable for use in cellular assays.
- High purity solid with characteristic orange to red color.
- Stable when stored sealed at -20°C; in solvent can be stored at -80°C for extended periods.
- Available in small milligram pack sizes suitable for research use.
LifeSensors Ubiquitin Mass Spectrometry Kit
Mass spectrometry (MS) proteomics, especially when combined with TUBE technologies for protein enrichment, can be used in several innovative and impactful applications. Quantitatively profiling the ubiquitome can lead to the identification of ubiquitination sites on target proteins, and by extension unveiling the mechanisms of undiscovered E3 ligases with their substrates. MS can also inform small molecule drug discovery for these targets (e.g. PROTACs, molecular glues) by quantitatively reporting on how much target protein is degraded in the presence or absence of a drug candidate. This approach can also greatly aid the discovery and development of novel diagnostic biomarkers for challenging disease targets and development of clinically monitoring disease progression. All these applications require a simple, label-free, rapid ubiquitome approach. This kit is designed to address this for rapid yet reproducible proteomics. *The plate is designed for research use only.
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.
Medchemexpress LLC LCC-12 formic | 3029253-76-4 | 99.85% | 460.57 | 25 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II).
- Leads to a decrease in the NAD(H) pool.
- Modulates inflammatory responses.
- Reduces inflammation in mouse models of bacterial and viral infections.
- Serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.